Howdy .45 (not long) Colt fans,
You are all missing a key point in the discussion. While a 45 Colt could do the job on a deer in many instances, knowing the exact range and trajectory is very important, but that's not the real point.
The point is that deer hunting is great reason for a new (old) gun. A nice old 94 in 30 WCF or 32 WCF would be a good choice and applicable to cowboy long range lever rifle. Of course, a 95 in 30/40 would be cool and .405 would probably be even cooler. And What about all those calibers in the new 76 Win clones. Other than abject poverty, there's really no reason to use a 45 for deer hunting.